Soft drug design – basic principles. The SD concept [ 3] is part of the more general recognition that drug design needs to (1) fully integrate metabolic considerations from the very beginning as metabolites contribute significantly to the overall activity and toxicity profile of the original drug. Figure 1. (2) focus not on improving activity.. Newsletter. A new study examines the blurry distinction between “hard” and “soft” drugs. The “hardness” of drugs is a concept that makes intuitive sense, but is difficult to put into precise terms. “Hard” drugs are those which are viewed as more addictive, more potent and more toxic than the comparatively benign “soft” variety.
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If you ask almost anyone if they know what a hard drug is, they’ll nod enthusiastically. Ask them to define a hard vs a soft drug however and the nodding might stop. According to most, hard drug s are more toxic, more dangerous, more addictive, more potent, just seemingly more. But it turns out that hardness is a measure of a drug ‘s potential for dependence, and its harm to the user.. Op lijst I van de Opiumwet staan de harddrugs. Deze zijn schadelijker voor de gezondheid dan softdrugs. Voorbeelden zijn heroïne, cocaïne, amfetamine, xtc en GHB. Op lijst II staan de softdrugs. De risico’s van deze drugs zijn minder groot dan bij de harddrugs op lijst I. Voorbeelden zijn cannabisproducten (hasj en wiet) en slaapmiddelen.
